| Week 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | |||||
| Week 1 | |||||
| Date | Game | Score | Time | ||
|---|---|---|---|---|---|
| 2009-09-10 | Tennessee Titans | at | Pittsburgh Steelers | 10 - 13 | Thu 8:30pm ET |
| 2009-09-13 | Kansas City Chiefs | at | Baltimore Ravens | 24 - 38 | Sun 1:00pm ET |
| 2009-09-13 | Philadelphia Eagles | at | Carolina Panthers | 38 - 10 | Sun 1:00pm ET |
| 2009-09-13 | Denver Broncos | at | Cincinnati Bengals | 12 - 7 | Sun 1:00pm ET |
| 2009-09-13 | Minnesota Vikings | at | Cleveland Browns | 34 - 20 | Sun 1:00pm ET |
| 2009-09-13 | Dallas Cowboys | at | Tampa Bay Bucs | 34 - 21 | Sun 1:00pm ET |
| 2009-09-13 | New York Jets | at | Houston Texans | 24 - 7 | Sun 1:00pm ET |
| 2009-09-13 | Detroit Lions | at | New Orleans Saints | 27 - 45 | Sun 1:00pm ET |
| 2009-09-13 | Jacksonville Jaguars | at | Indianapolis Colts | 12 - 14 | Sun 1:00pm ET |
| 2009-09-13 | Miami Dolphins | at | Atlanta Falcons | 7 - 19 | Sun 1:00pm ET |
| 2009-09-13 | San Francisco 49ers | at | Arizona Cardinals | 20 - 16 | Sun 4:15pm ET |
| 2009-09-13 | St. Louis Rams | at | Seattle Seahawks | 0 - 28 | Sun 4:15pm ET |
| 2009-09-13 | Washington Redskins | at | New York Giants | 17 - 23 | Sun 4:15pm ET |
| 2009-09-13 | Chicago Bears | at | Green Bay Packers | 15 - 21 | Sun 8:30pm ET |
| 2009-09-14 | Buffalo Bills | at | New England Patriots | 24 - 25 | Mon 7:00pm ET |
| 2009-09-14 | San Diego Chargers | at | Oakland Raiders | 24 - 20 | Mon 10:15pm ET |
| Week 2 | |||||
| Date | Game | Score | Time | ||
| 2009-09-20 | Arizona Cardinals | at | Jacksonville Jaguars | 31 - 17 | Sun 1:00pm ET |
| 2009-09-20 | Carolina Panthers | at | Atlanta Falcons | 20 - 28 | Sun 1:00pm ET |
| 2009-09-20 | Oakland Raiders | at | Kansas City Chiefs | 13 - 10 | Sun 1:00pm ET |
| 2009-09-20 | New Orleans Saints | at | Philadelphia Eagles | 48 - 22 | Sun 1:00pm ET |
| 2009-09-20 | New England Patriots | at | New York Jets | 9 - 16 | Sun 1:00pm ET |
| 2009-09-20 | Minnesota Vikings | at | Detroit Lions | 27 - 13 | Sun 1:00pm ET |
| 2009-09-20 | Houston Texans | at | Tennessee Titans | 34 - 31 | Sun 1:00pm ET |
| 2009-09-20 | St. Louis Rams | at | Washington Redskins | 7 - 9 | Sun 1:00pm ET |
| 2009-09-20 | Cincinnati Bengals | at | Green Bay Packers | 31 - 24 | Sun 1:00pm ET |
| 2009-09-20 | Tampa Bay Bucs | at | Buffalo Bills | 20 - 33 | Sun 4:05pm ET |
| 2009-09-20 | Seattle Seahawks | at | San Francisco 49ers | 10 - 23 | Sun 4:05pm ET |
| 2009-09-20 | Baltimore Ravens | at | San Diego Chargers | 31 - 26 | Sun 4:15pm ET |
| 2009-09-20 | Pittsburgh Steelers | at | Chicago Bears | 14 - 17 | Sun 4:15pm ET |
| 2009-09-20 | Cleveland Browns | at | Denver Broncos | 6 - 27 | Sun 4:15pm ET |
| 2009-09-20 | New York Giants | at | Dallas Cowboys | 33 - 31 | Sun 8:20pm ET |
| 2009-09-21 | Indianapolis Colts | at | Miami Dolphins | 27 - 23 | Mon 8:30pm ET |
| Week 3 | |||||
| Date | Game | Score | Time | ||
| 2009-09-27 | New York Giants | at | Tampa Bay Bucs | 24 - 0 | Sun 1:00pm ET |
| 2009-09-27 | Jacksonville Jaguars | at | Houston Texans | 31 - 24 | Sun 1:00pm ET |
| 2009-09-27 | San Francisco 49ers | at | Minnesota Vikings | 24 - 27 | Sun 1:00pm ET |
| 2009-09-27 | Green Bay Packers | at | St. Louis Rams | 36 - 17 | Sun 1:00pm ET |
| 2009-09-27 | Kansas City Chiefs | at | Philadelphia Eagles | 14 - 34 | Sun 1:00pm ET |
| 2009-09-27 | Cleveland Browns | at | Baltimore Ravens | 3 - 34 | Sun 1:00pm ET |
| 2009-09-27 | Atlanta Falcons | at | New England Patriots | 10 - 26 | Sun 1:00pm ET |
| 2009-09-27 | Tennessee Titans | at | New York Jets | 17 - 24 | Sun 1:00pm ET |
| 2009-09-27 | Washington Redskins | at | Detroit Lions | 14 - 19 | Sun 1:00pm ET |
| 2009-09-27 | Chicago Bears | at | Seattle Seahawks | 25 - 19 | Sun 4:05pm ET |
| 2009-09-27 | New Orleans Saints | at | Buffalo Bills | 27 - 7 | Sun 4:05pm ET |
| 2009-09-27 | Pittsburgh Steelers | at | Cincinnati Bengals | 20 - 23 | Sun 4:15pm ET |
| 2009-09-27 | Denver Broncos | at | Oakland Raiders | 23 - 3 | Sun 4:15pm ET |
| 2009-09-27 | Miami Dolphins | at | San Diego Chargers | 13 - 23 | Sun 4:15pm ET |
| 2009-09-27 | Indianapolis Colts | at | Arizona Cardinals | 31 - 10 | Sun 8:20pm ET |
| 2009-09-28 | Carolina Panthers | at | Dallas Cowboys | 7 - 21 | Mon 8:30pm ET |
| Week 4 | |||||
| Date | Game | Score | Time | ||
| 2009-10-04 | Oakland Raiders | at | Houston Texans | 6 - 29 | Sun 1:00pm ET |
| 2009-10-04 | Tampa Bay Bucs | at | Washington Redskins | 13 - 16 | Sun 1:00pm ET |
| 2009-10-04 | Baltimore Ravens | at | New England Patriots | 21 - 27 | Sun 1:00pm ET |
| 2009-10-04 | Detroit Lions | at | Chicago Bears | 24 - 48 | Sun 1:00pm ET |
| 2009-10-04 | Seattle Seahawks | at | Indianapolis Colts | 17 - 34 | Sun 1:00pm ET |
| 2009-10-04 | Tennessee Titans | at | Jacksonville Jaguars | 17 - 37 | Sun 1:00pm ET |
| 2009-10-04 | New York Giants | at | Kansas City Chiefs | 27 - 16 | Sun 1:00pm ET |
| 2009-10-04 | Cincinnati Bengals | at | Cleveland Browns | 23 - 20 | Sun 1:00pm ET |
| 2009-10-04 | New York Jets | at | New Orleans Saints | 10 - 24 | Sun 4:05pm ET |
| 2009-10-04 | Buffalo Bills | at | Miami Dolphins | 10 - 38 | Sun 4:05pm ET |
| 2009-10-04 | St. Louis Rams | at | San Francisco 49ers | 0 - 35 | Sun 4:15pm ET |
| 2009-10-04 | Dallas Cowboys | at | Denver Broncos | 10 - 17 | Sun 4:15pm ET |
| 2009-10-04 | San Diego Chargers | at | Pittsburgh Steelers | 28 - 38 | Sun 8:20pm ET |
| 2009-10-05 | Green Bay Packers | at | Minnesota Vikings | 23 - 30 | Mon 8:20pm ET |
| Carolina Panthers on BYE | |||||
| Arizona Cardinals on BYE | |||||
| Atlanta Falcons on BYE | |||||
| Philadelphia Eagles on BYE | |||||
| Week 5 | |||||
| Date | Game | Score | Time | ||
| 2009-10-11 | Cleveland Browns | at | Buffalo Bills | 6 - 3 | Sun 1:00pm ET |
| 2009-10-11 | Washington Redskins | at | Carolina Panthers | 17 - 20 | Sun 1:00pm ET |
| 2009-10-11 | Oakland Raiders | at | New York Giants | 7 - 44 | Sun 1:00pm ET |
| 2009-10-11 | Tampa Bay Bucs | at | Philadelphia Eagles | 14 - 33 | Sun 1:00pm ET |
| 2009-10-11 | Pittsburgh Steelers | at | Detroit Lions | 28 - 20 | Sun 1:00pm ET |
| 2009-10-11 | Dallas Cowboys | at | Kansas City Chiefs | 26 - 20 | Sun 1:00pm ET |
| 2009-10-11 | Minnesota Vikings | at | St. Louis Rams | 38 - 10 | Sun 1:00pm ET |
| 2009-10-11 | Cincinnati Bengals | at | Baltimore Ravens | 17 - 14 | Sun 1:00pm ET |
| 2009-10-11 | Atlanta Falcons | at | San Francisco 49ers | 45 - 10 | Sun 4:05pm ET |
| 2009-10-11 | Houston Texans | at | Arizona Cardinals | 21 - 28 | Sun 4:15pm ET |
| 2009-10-11 | New England Patriots | at | Denver Broncos | 17 - 20 | Sun 4:15pm ET |
| 2009-10-11 | Jacksonville Jaguars | at | Seattle Seahawks | 0 - 41 | Sun 4:15pm ET |
| 2009-10-11 | Indianapolis Colts | at | Tennessee Titans | 31 - 9 | Sun 8:20pm ET |
| 2009-10-12 | New York Jets | at | Miami Dolphins | 27 - 31 | Mon 8:20pm ET |
| Chicago Bears on BYE | |||||
| Green Bay Packers on BYE | |||||
| Week 6 | |||||
| Date | Game | Score | Time | ||
| 2009-10-18 | Cleveland Browns | at | Pittsburgh Steelers | 14 - 27 | Sun 1:00pm ET |
| 2009-10-18 | Carolina Panthers | at | Tampa Bay Bucs | 28 - 21 | Sun 1:00pm ET |
| 2009-10-18 | Baltimore Ravens | at | Minnesota Vikings | 31 - 33 | Sun 1:00pm ET |
| 2009-10-18 | Houston Texans | at | Cincinnati Bengals | 28 - 17 | Sun 1:00pm ET |
| 2009-10-18 | St. Louis Rams | at | Jacksonville Jaguars | 20 - 23 | Sun 1:00pm ET |
| 2009-10-18 | Kansas City Chiefs | at | Washington Redskins | 14 - 6 | Sun 1:00pm ET |
| 2009-10-18 | New York Giants | at | New Orleans Saints | 27 - 48 | Sun 1:00pm ET |
| 2009-10-18 | Detroit Lions | at | Green Bay Packers | 0 - 26 | Sun 1:00pm ET |
| 2009-10-18 | Philadelphia Eagles | at | Oakland Raiders | 9 - 13 | Sun 4:05pm ET |
| 2009-10-18 | Arizona Cardinals | at | Seattle Seahawks | 27 - 3 | Sun 4:05pm ET |
| 2009-10-18 | Tennessee Titans | at | New England Patriots | 0 - 59 | Sun 4:15pm ET |
| 2009-10-18 | Buffalo Bills | at | New York Jets | 16 - 13 | Sun 4:15pm ET |
| 2009-10-18 | Chicago Bears | at | Atlanta Falcons | 14 - 21 | Sun 8:20pm ET |
| 2009-10-19 | Denver Broncos | at | San Diego Chargers | 34 - 23 | Mon 8:20pm ET |
| Miami Dolphins on BYE | |||||
| San Francisco 49ers on BYE | |||||
| Dallas Cowboys on BYE | |||||
| Week 7 | |||||
| Date | Game | Score | Time | ||
| 2009-10-25 | Green Bay Packers | at | Cleveland Browns | 31 - 3 | Sun 1:00pm ET |
| 2009-10-25 | San Diego Chargers | at | Kansas City Chiefs | 37 - 7 | Sun 1:00pm ET |
| 2009-10-25 | San Francisco 49ers | at | Houston Texans | 21 - 24 | Sun 1:00pm ET |
| 2009-10-25 | Minnesota Vikings | at | Pittsburgh Steelers | 17 - 27 | Sun 1:00pm ET |
| 2009-10-25 | Indianapolis Colts | at | St. Louis Rams | 42 - 6 | Sun 1:00pm ET |
| 2009-10-25 | New England Patriots | at | Tampa Bay Bucs | 35 - 7 | Sun 1:00pm ET |
| 2009-10-25 | New York Jets | at | Oakland Raiders | 38 - 0 | Sun 4:05pm ET |
| 2009-10-25 | Buffalo Bills | at | Carolina Panthers | 20 - 9 | Sun 4:05pm ET |
| 2009-10-25 | Chicago Bears | at | Cincinnati Bengals | 10 - 45 | Sun 4:15pm ET |
| 2009-10-25 | New Orleans Saints | at | Miami Dolphins | 46 - 34 | Sun 4:15pm ET |
| 2009-10-25 | Atlanta Falcons | at | Dallas Cowboys | 21 - 37 | Sun 4:15pm ET |
| 2009-10-25 | Arizona Cardinals | at | New York Giants | 24 - 17 | Sun 8:20pm ET |
| 2009-10-26 | Philadelphia Eagles | at | Washington Redskins | 27 - 17 | Mon 8:30pm ET |
| Tennessee Titans on BYE | |||||
| Seattle Seahawks on BYE | |||||
| Jacksonville Jaguars on BYE | |||||
| Detroit Lions on BYE | |||||
| Denver Broncos on BYE | |||||
| Baltimore Ravens on BYE | |||||
| Week 8 | |||||
| Date | Game | Score | Time | ||
| 2009-11-01 | Miami Dolphins | at | New York Jets | 30 - 25 | Sun 1:00pm ET |
| 2009-11-01 | San Francisco 49ers | at | Indianapolis Colts | 14 - 18 | Sun 1:00pm ET |
| 2009-11-01 | St. Louis Rams | at | Detroit Lions | 17 - 10 | Sun 1:00pm ET |
| 2009-11-01 | Seattle Seahawks | at | Dallas Cowboys | 17 - 38 | Sun 1:00pm ET |
| 2009-11-01 | New York Giants | at | Philadelphia Eagles | 17 - 40 | Sun 1:00pm ET |
| 2009-11-01 | Cleveland Browns | at | Chicago Bears | 6 - 30 | Sun 1:00pm ET |
| 2009-11-01 | Houston Texans | at | Buffalo Bills | 31 - 10 | Sun 1:00pm ET |
| 2009-11-01 | Denver Broncos | at | Baltimore Ravens | 7 - 30 | Sun 1:00pm ET |
| 2009-11-01 | Oakland Raiders | at | San Diego Chargers | 16 - 24 | Sun 4:05pm ET |
| 2009-11-01 | Jacksonville Jaguars | at | Tennessee Titans | 13 - 30 | Sun 4:05pm ET |
| 2009-11-01 | Carolina Panthers | at | Arizona Cardinals | 34 - 21 | Sun 4:15pm ET |
| 2009-11-01 | Minnesota Vikings | at | Green Bay Packers | 38 - 26 | Sun 4:15pm ET |
| 2009-11-02 | Atlanta Falcons | at | New Orleans Saints | 27 - 35 | Mon 8:30pm ET |
| Kansas City Chiefs on BYE | |||||
| New England Patriots on BYE | |||||
| Cincinnati Bengals on BYE | |||||
| Pittsburgh Steelers on BYE | |||||
| Tampa Bay Bucs on BYE | |||||
| Washington Redskins on BYE | |||||
| Week 9 | |||||
| Date | Game | Score | Time | ||
| 2009-11-08 | Arizona Cardinals | at | Chicago Bears | 41 - 21 | Sun 1:00pm ET |
| 2009-11-08 | Washington Redskins | at | Atlanta Falcons | 17 - 31 | Sun 1:00pm ET |
| 2009-11-08 | Baltimore Ravens | at | Cincinnati Bengals | 7 - 17 | Sun 1:00pm ET |
| 2009-11-08 | Green Bay Packers | at | Tampa Bay Bucs | 28 - 38 | Sun 1:00pm ET |
| 2009-11-08 | Houston Texans | at | Indianapolis Colts | 17 - 20 | Sun 1:00pm ET |
| 2009-11-08 | Kansas City Chiefs | at | Jacksonville Jaguars | 21 - 24 | Sun 1:00pm ET |
| 2009-11-08 | Miami Dolphins | at | New England Patriots | 17 - 27 | Sun 1:00pm ET |
| 2009-11-08 | Carolina Panthers | at | New Orleans Saints | 20 - 30 | Sun 4:05pm ET |
| 2009-11-08 | Detroit Lions | at | Seattle Seahawks | 20 - 32 | Sun 4:05pm ET |
| 2009-11-08 | Tennessee Titans | at | San Francisco 49ers | 34 - 27 | Sun 4:15pm ET |
| 2009-11-08 | San Diego Chargers | at | New York Giants | 21 - 20 | Sun 4:15pm ET |
| 2009-11-08 | Dallas Cowboys | at | Philadelphia Eagles | 20 - 16 | Sun 8:20pm ET |
| 2009-11-09 | Pittsburgh Steelers | at | Denver Broncos | 28 - 10 | Mon 8:30pm ET |
| Cleveland Browns on BYE | |||||
| New York Jets on BYE | |||||
| Oakland Raiders on BYE | |||||
| Buffalo Bills on BYE | |||||
| St. Louis Rams on BYE | |||||
| Week 10 | |||||
| Date | Game | Score | Time | ||
| 2009-11-12 | Chicago Bears | at | San Francisco 49ers | 6 - 10 | Thu 8:20pm ET |
| 2009-11-15 | Tampa Bay Bucs | at | Miami Dolphins | 23 - 25 | Sun 1:00pm ET |
| 2009-11-15 | Jacksonville Jaguars | at | New York Jets | 24 - 22 | Sun 1:00pm ET |
| 2009-11-15 | Detroit Lions | at | Minnesota Vikings | 10 - 27 | Sun 1:00pm ET |
| 2009-11-15 | New Orleans Saints | at | St. Louis Rams | 28 - 23 | Sun 1:00pm ET |
| 2009-11-15 | Cincinnati Bengals | at | Pittsburgh Steelers | 18 - 12 | Sun 1:00pm ET |
| 2009-11-15 | Buffalo Bills | at | Tennessee Titans | 17 - 41 | Sun 1:00pm ET |
| 2009-11-15 | Atlanta Falcons | at | Carolina Panthers | 19 - 28 | Sun 1:00pm ET |
| 2009-11-15 | Denver Broncos | at | Washington Redskins | 17 - 27 | Sun 1:00pm ET |
| 2009-11-15 | Kansas City Chiefs | at | Oakland Raiders | 16 - 10 | Sun 4:05pm ET |
| 2009-11-15 | Philadelphia Eagles | at | San Diego Chargers | 23 - 31 | Sun 4:15pm ET |
| 2009-11-15 | Dallas Cowboys | at | Green Bay Packers | 7 - 17 | Sun 4:15pm ET |
| 2009-11-15 | Seattle Seahawks | at | Arizona Cardinals | 20 - 31 | Sun 4:15pm ET |
| 2009-11-15 | New England Patriots | at | Indianapolis Colts | 34 - 35 | Sun 8:20pm ET |
| 2009-11-16 | Baltimore Ravens | at | Cleveland Browns | 16 - 0 | Mon 8:30pm ET |
| New York Giants on BYE | |||||
| Houston Texans on BYE | |||||
| Week 11 | |||||
| Date | Game | Score | Time | ||
| 2009-11-19 | Miami Dolphins | at | Carolina Panthers | 24 - 17 | Thu 8:20pm ET |
| 2009-11-22 | Atlanta Falcons | at | New York Giants | 31 - 34 | Sun 1:00pm ET |
| 2009-11-22 | Indianapolis Colts | at | Baltimore Ravens | 17 - 15 | Sun 1:00pm ET |
| 2009-11-22 | New Orleans Saints | at | Tampa Bay Bucs | 38 - 7 | Sun 1:00pm ET |
| 2009-11-22 | Seattle Seahawks | at | Minnesota Vikings | 9 - 35 | Sun 1:00pm ET |
| 2009-11-22 | San Francisco 49ers | at | Green Bay Packers | 24 - 30 | Sun 1:00pm ET |
| 2009-11-22 | Washington Redskins | at | Dallas Cowboys | 6 - 7 | Sun 1:00pm ET |
| 2009-11-22 | Pittsburgh Steelers | at | Kansas City Chiefs | 24 - 27 | Sun 1:00pm ET |
| 2009-11-22 | Cleveland Browns | at | Detroit Lions | 37 - 38 | Sun 1:00pm ET |
| 2009-11-22 | Buffalo Bills | at | Jacksonville Jaguars | 15 - 18 | Sun 1:00pm ET |
| 2009-11-22 | Arizona Cardinals | at | St. Louis Rams | 21 - 13 | Sun 4:05pm ET |
| 2009-11-22 | Cincinnati Bengals | at | Oakland Raiders | 17 - 20 | Sun 4:15pm ET |
| 2009-11-22 | San Diego Chargers | at | Denver Broncos | 32 - 3 | Sun 4:15pm ET |
| 2009-11-22 | New York Jets | at | New England Patriots | 14 - 31 | Sun 4:15pm ET |
| 2009-11-22 | Philadelphia Eagles | at | Chicago Bears | 24 - 20 | Sun 8:20pm ET |
| 2009-11-23 | Tennessee Titans | at | Houston Texans | 20 - 17 | Mon 8:30pm ET |
| Week 12 | |||||
| Date | Game | Score | Time | ||
| 2009-11-26 | Green Bay Packers | at | Detroit Lions | 34 - 12 | Thu 12:30pm ET |
| 2009-11-26 | Oakland Raiders | at | Dallas Cowboys | 7 - 24 | Thu 4:15pm ET |
| 2009-11-26 | New York Giants | at | Denver Broncos | 6 - 26 | Thu 8:20pm ET |
| 2009-11-29 | Tampa Bay Bucs | at | Atlanta Falcons | 17 - 20 | Sun 1:00pm ET |
| 2009-11-29 | Miami Dolphins | at | Buffalo Bills | 14 - 31 | Sun 1:00pm ET |
| 2009-11-29 | Carolina Panthers | at | New York Jets | 6 - 17 | Sun 1:00pm ET |
| 2009-11-29 | Cleveland Browns | at | Cincinnati Bengals | 7 - 16 | Sun 1:00pm ET |
| 2009-11-29 | Washington Redskins | at | Philadelphia Eagles | 24 - 27 | Sun 1:00pm ET |
| 2009-11-29 | Indianapolis Colts | at | Houston Texans | 35 - 27 | Sun 1:00pm ET |
| 2009-11-29 | Seattle Seahawks | at | St. Louis Rams | 27 - 17 | Sun 1:00pm ET |
| 2009-11-29 | Kansas City Chiefs | at | San Diego Chargers | 14 - 43 | Sun 4:05pm ET |
| 2009-11-29 | Jacksonville Jaguars | at | San Francisco 49ers | 3 - 20 | Sun 4:05pm ET |
| 2009-11-29 | Arizona Cardinals | at | Tennessee Titans | 17 - 20 | Sun 4:15pm ET |
| 2009-11-29 | Chicago Bears | at | Minnesota Vikings | 10 - 36 | Sun 4:15pm ET |
| 2009-11-29 | Pittsburgh Steelers | at | Baltimore Ravens | 17 - 20 | Sun 8:20pm ET |
| 2009-11-30 | New England Patriots | at | New Orleans Saints | 17 - 38 | Mon 8:30pm ET |
| Week 13 | |||||
| Date | Game | Score | Time | ||
| 2009-12-03 | New York Jets | at | Buffalo Bills | 19 - 13 | Thu 8:20pm ET |
| 2009-12-06 | Denver Broncos | at | Kansas City Chiefs | 44 - 13 | Sun 1:00pm ET |
| 2009-12-06 | Tampa Bay Bucs | at | Carolina Panthers | 6 - 16 | Sun 1:00pm ET |
| 2009-12-06 | Philadelphia Eagles | at | Atlanta Falcons | 34 - 7 | Sun 1:00pm ET |
| 2009-12-06 | New England Patriots | at | Miami Dolphins | 21 - 22 | Sun 1:00pm ET |
| 2009-12-06 | St. Louis Rams | at | Chicago Bears | 9 - 17 | Sun 1:00pm ET |
| 2009-12-06 | Detroit Lions | at | Cincinnati Bengals | 13 - 23 | Sun 1:00pm ET |
| 2009-12-06 | Oakland Raiders | at | Pittsburgh Steelers | 27 - 24 | Sun 1:00pm ET |
| 2009-12-06 | Houston Texans | at | Jacksonville Jaguars | 18 - 23 | Sun 1:00pm ET |
| 2009-12-06 | New Orleans Saints | at | Washington Redskins | 33 - 30 | Sun 1:00pm ET |
| 2009-12-06 | Tennessee Titans | at | Indianapolis Colts | 17 - 27 | Sun 1:00pm ET |
| 2009-12-06 | San Diego Chargers | at | Cleveland Browns | 30 - 23 | Sun 4:05pm ET |
| 2009-12-06 | San Francisco 49ers | at | Seattle Seahawks | 17 - 20 | Sun 4:15pm ET |
| 2009-12-06 | Dallas Cowboys | at | New York Giants | 24 - 31 | Sun 4:15pm ET |
| 2009-12-06 | Minnesota Vikings | at | Arizona Cardinals | 17 - 30 | Sun 8:20pm ET |
| 2009-12-07 | Baltimore Ravens | at | Green Bay Packers | 14 - 27 | Mon 8:30pm ET |
| Week 14 | |||||
| Date | Game | Score | Time | ||
| 2009-12-10 | Pittsburgh Steelers | at | Cleveland Browns | 6 - 13 | Thu 8:20pm ET |
| 2009-12-13 | Green Bay Packers | at | Chicago Bears | 21 - 14 | Sun 1:00pm ET |
| 2009-12-13 | Cincinnati Bengals | at | Minnesota Vikings | 10 - 30 | Sun 1:00pm ET |
| 2009-12-13 | Denver Broncos | at | Indianapolis Colts | 16 - 28 | Sun 1:00pm ET |
| 2009-12-13 | Carolina Panthers | at | New England Patriots | 10 - 20 | Sun 1:00pm ET |
| 2009-12-13 | Buffalo Bills | at | Kansas City Chiefs | 16 - 10 | Sun 1:00pm ET |
| 2009-12-13 | Miami Dolphins | at | Jacksonville Jaguars | 14 - 10 | Sun 1:00pm ET |
| 2009-12-13 | New York Jets | at | Tampa Bay Bucs | 26 - 3 | Sun 1:00pm ET |
| 2009-12-13 | Seattle Seahawks | at | Houston Texans | 7 - 34 | Sun 1:00pm ET |
| 2009-12-13 | Detroit Lions | at | Baltimore Ravens | 3 - 48 | Sun 1:00pm ET |
| 2009-12-13 | New Orleans Saints | at | Atlanta Falcons | 26 - 23 | Sun 1:00pm ET |
| 2009-12-13 | St. Louis Rams | at | Tennessee Titans | 7 - 47 | Sun 4:05pm ET |
| 2009-12-13 | Washington Redskins | at | Oakland Raiders | 34 - 13 | Sun 4:05pm ET |
| 2009-12-13 | San Diego Chargers | at | Dallas Cowboys | 20 - 17 | Sun 4:15pm ET |
| 2009-12-13 | Philadelphia Eagles | at | New York Giants | 45 - 38 | Sun 8:20pm ET |
| 2009-12-14 | Arizona Cardinals | at | San Francisco 49ers | 9 - 24 | Mon 8:30pm ET |
| Week 15 | |||||
| Date | Game | Score | Time | ||
| 2009-12-17 | Indianapolis Colts | at | Jacksonville Jaguars | 35 - 31 | Thu 8:20pm ET |
| 2009-12-19 | Dallas Cowboys | at | New Orleans Saints | 24 - 17 | Sat 8:20pm ET |
| 2009-12-20 | Arizona Cardinals | at | Detroit Lions | 31 - 24 | Sun 1:00pm ET |
| 2009-12-20 | Atlanta Falcons | at | New York Jets | 10 - 7 | Sun 1:00pm ET |
| 2009-12-20 | New England Patriots | at | Buffalo Bills | 17 - 10 | Sun 1:00pm ET |
| 2009-12-20 | Cleveland Browns | at | Kansas City Chiefs | 41 - 34 | Sun 1:00pm ET |
| 2009-12-20 | Houston Texans | at | St. Louis Rams | 16 - 13 | Sun 1:00pm ET |
| 2009-12-20 | Miami Dolphins | at | Tennessee Titans | 24 - 27 | Sun 1:00pm ET |
| 2009-12-20 | Oakland Raiders | at | Denver Broncos | 20 - 19 | Sun 4:05pm ET |
| 2009-12-20 | Cincinnati Bengals | at | San Diego Chargers | 24 - 27 | Sun 4:05pm ET |
| 2009-12-20 | Chicago Bears | at | Baltimore Ravens | 7 - 31 | Sun 4:15pm ET |
| 2009-12-20 | San Francisco 49ers | at | Philadelphia Eagles | 13 - 27 | Sun 4:15pm ET |
| 2009-12-20 | Green Bay Packers | at | Pittsburgh Steelers | 36 - 37 | Sun 4:15pm ET |
| 2009-12-20 | Tampa Bay Bucs | at | Seattle Seahawks | 24 - 7 | Sun 4:15pm ET |
| 2009-12-20 | Minnesota Vikings | at | Carolina Panthers | 7 - 26 | Sun 8:20pm ET |
| 2009-12-21 | New York Giants | at | Washington Redskins | 45 - 12 | Mon 8:30pm ET |
| Week 16 | |||||
| Date | Game | Score | Time | ||
| 2009-12-25 | San Diego Chargers | at | Tennessee Titans | 42 - 17 | Fri 7:30pm ET |
| 2009-12-27 | Buffalo Bills | at | Atlanta Falcons | 3 - 31 | Sun 1:00pm ET |
| 2009-12-27 | Baltimore Ravens | at | Pittsburgh Steelers | 20 - 23 | Sun 1:00pm ET |
| 2009-12-27 | Houston Texans | at | Miami Dolphins | 27 - 20 | Sun 1:00pm ET |
| 2009-12-27 | Carolina Panthers | at | New York Giants | 41 - 9 | Sun 1:00pm ET |
| 2009-12-27 | Kansas City Chiefs | at | Cincinnati Bengals | 10 - 17 | Sun 1:00pm ET |
| 2009-12-27 | Oakland Raiders | at | Cleveland Browns | 9 - 23 | Sun 1:00pm ET |
| 2009-12-27 | Seattle Seahawks | at | Green Bay Packers | 10 - 48 | Sun 1:00pm ET |
| 2009-12-27 | Tampa Bay Bucs | at | New Orleans Saints | 20 - 17 | Sun 1:00pm ET |
| 2009-12-27 | Jacksonville Jaguars | at | New England Patriots | 7 - 35 | Sun 1:00pm ET |
| 2009-12-27 | St. Louis Rams | at | Arizona Cardinals | 10 - 31 | Sun 4:05pm ET |
| 2009-12-27 | Detroit Lions | at | San Francisco 49ers | 6 - 20 | Sun 4:05pm ET |
| 2009-12-27 | Denver Broncos | at | Philadelphia Eagles | 27 - 30 | Sun 4:15pm ET |
| 2009-12-27 | New York Jets | at | Indianapolis Colts | 29 - 15 | Sun 4:15pm ET |
| 2009-12-27 | Dallas Cowboys | at | Washington Redskins | 17 - 0 | Sun 8:20pm ET |
| 2009-12-28 | Minnesota Vikings | at | Chicago Bears | 30 - 36 | Mon 8:30pm ET |
| Week 17 | |||||
| Date | Game | Score | Time | ||
| 2010-01-03 | San Francisco 49ers | at | St. Louis Rams | 28 - 6 | Sun 1:00pm ET |
| 2010-01-03 | Jacksonville Jaguars | at | Cleveland Browns | 17 - 23 | Sun 1:00pm ET |
| 2010-01-03 | Atlanta Falcons | at | Tampa Bay Bucs | 20 - 10 | Sun 1:00pm ET |
| 2010-01-03 | Indianapolis Colts | at | Buffalo Bills | 7 - 30 | Sun 1:00pm ET |
| 2010-01-03 | New Orleans Saints | at | Carolina Panthers | 10 - 23 | Sun 1:00pm ET |
| 2010-01-03 | New England Patriots | at | Houston Texans | 27 - 34 | Sun 1:00pm ET |
| 2010-01-03 | Chicago Bears | at | Detroit Lions | 37 - 23 | Sun 1:00pm ET |
| 2010-01-03 | New York Giants | at | Minnesota Vikings | 7 - 44 | Sun 1:00pm ET |
| 2010-01-03 | Pittsburgh Steelers | at | Miami Dolphins | 30 - 24 | Sun 1:00pm ET |
| 2010-01-03 | Philadelphia Eagles | at | Dallas Cowboys | 0 - 24 | Sun 4:15pm ET |
| 2010-01-03 | Tennessee Titans | at | Seattle Seahawks | 17 - 13 | Sun 4:15pm ET |
| 2010-01-03 | Kansas City Chiefs | at | Denver Broncos | 44 - 24 | Sun 4:15pm ET |
| 2010-01-03 | Washington Redskins | at | San Diego Chargers | 20 - 23 | Sun 4:15pm ET |
| 2010-01-03 | Baltimore Ravens | at | Oakland Raiders | 21 - 13 | Sun 4:15pm ET |
| 2010-01-03 | Green Bay Packers | at | Arizona Cardinals | 33 - 7 | Sun 4:15pm ET |
| 2010-01-03 | Cincinnati Bengals | at | New York Jets | 0 - 37 | Sun 8:30pm ET |